Citrus auraptene induces drug efflux transporter p-glycoprotein expression

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-PAA-010
• By: NABEKURA, Tomohiro (Aichi Gakuin University, School of Pharmacy)
• Co-author(s): Tomohiro NABEKURA
  Tatsuya KAWASAKI: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
  Kazuyoshi KAWAI: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
  Yu KATO: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
  Yuichi UWAI: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
  
• Abstract:

  Background

       P-glycoprotein (MDR1, ABCB1) is a membrane transport protein that is expressed in the intestine, liver, kidney, placenta, and blood-brain barrier.  P-glycoprotein excludes various clinically important drugs, such as verapamil, digoxin, tacrolimus, and vinblastine, from the cells.  Therefore, human P-glycoprotein plays important..

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