Intracellular unbound drug concentrations: Methodology and application for understanding cellular drug exposure

• In: Symposium B1: Towards understanding compound disposition at ever higher spatial resolution by label free methods on Monday, 22 May 2017, 15:05-15:35
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: MATEUS, André (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
• Co-author(s): André Mateus: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden;Science for Life Laboratory Drug Discovery and Development Platform (SciLifelab-DDDP), Uppsala University, Uppsala, Sweden
  
• Abstract:

  The cell interior contains a large number of drug targets. Interactions with these proteins are determined by the intracellular unbound drug concentration. In this presentation, I will present a recently published methodology (Mateus et al., Mol Pharmaceutics, 2013; Mateus et al., J Med Chem, 2014) to predict drug access to intracellular targets

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