Therapeutic efficacy and safety of long-term stored hemoglobin-vesicles in a rat model of hemorrhagic shock

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-C-035-Tuesday
• By: TOKUNO, Masahiro (Sojo University, Kumamoto, Japan)
• Co-author(s): Masahiro Tokuno: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
  Kazuaki Taguchi: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
  Keishi Yamasaki: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;DDS Research Institute, Sojo University, Kumamoto, Japan
  Hiromi Sakai: Department of Chemistry, Nara Medical University, Nara, Japan
  Masaki Otagiri: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;DDS Research Institute, Sojo University, Kumamoto, Japan
  
• Abstract:

  Backgrounds

  Hemoglobin-vesicles (HbV) have been developed as red blood cell (RBC) substitutes. In vitro experiments showed that HbV suspensions are structurally and physicochemically stabile for a year, which indicate that HbV can be stored for more than 1 year. However, it remains unclear that long-term stored HbV administration could effectively..

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