siRNA loaded pH-responsive and Tumor-targeted Nano-carries for Inhibiting Tumor Growth and Metastasis in Cancer therapy

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-082-Tuesday
• By: GAO, Zhonggao (Chinese Academy of Medical Sciences, Pharmaceutics, Beijing, China)
• Co-author(s): Zhonggao Gao: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
  Bo Fan: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
  Wei Huang: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
  Lin kang: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
  
• Abstract:

  Backgrounds

  A novel pH-activated “sheddable” PEG-coated nanoparticle was constructed for effective treatment of primary tumors and metastases, which was based on the conjugation of catechol group modified poly(ethylene glycol) (PEG-Cat) and PBA-terminated polyethylenimine (PEI-PBA) via the borate ester formed between PBA and Cat.

  Aims

  To prepare dual
  ..

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