Physiologically-based approach to predict dopamine D2 receptor occupancy of antipsychotics in brain: translation from rat to human

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-092-Tuesday
• By: WONG, Yin Cheong (Leiden University, Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands)
• Co-author(s): Yin Cheong Wong: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden Univeristy, Leiden, Netherlands
  Maddalena Centanni: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden Univeristy, Leiden, Netherlands
  
  Elizabeth de Lange: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands
  
• Abstract:

  Backgrounds

  Receptor occupancy (RO) is a translational biomarker for assessing drug efficacy, which could facilitate both dose optimization of existing drugs and evaluation of drug candidates.

   

  Aims

  We aimed to apply a physiologically-based pharmacokinetic (PBPK) modeling approach to predict the dopamine D2 RO of antipsychotics. 

   

  Methods

  Risperidone

  ..

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