Development of a generic physiologically based pharmacokinetic model to predict drug target site concentrations in the CNS

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-111-Monday
• By: YAMAMOTO, Yumi (Leiden University, LACDR, Pharmacology, Leiden, Netherlands)
• Co-author(s): Yumi Yamamoto: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  Pyry A. Välitalo: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  Dirk-Jan van den Berg: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  Robin Hartman: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  Yin Cheong Wong: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  Dymphy R. Huntjens: Quantitative Sciences, Janssen Research & Development, Beerse, Belgium
  Johannes H. Proost: Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, Netherlands
  An Vermeulen: Quantitative Sciences, Janssen Research & Development, Beerse, Belgium
  Walter Krauwinkel: Clinical Pharmacology & Exploratory Development, Astellas Pharma BV, Leiden, Netherlands
  Meindert Danhof: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  Johan G. C. van Hasselt: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  Elizabeth C. M. de Lange: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
  
• Abstract:

  Backgrounds

  Predicting human target site concentrations in the central nervous system (CNS) is challenging because of the presence of the blood-brain barrier and the blood-cerebrospinal fluid barrier. Furthermore, access to human brain samples is restricted because of practical and ethical reasons. A physiologically based pharmacokinetic (PBPK)..

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