Pharmacokinetics in zebrafish larvae: characterizing acetaminophen absorption and clearance in maturing larvae

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-104-Monday
• By: VAN WIJK, Rob Christiaan (LACDR, Cluster Systems Pharmacology, Leiden, Netherlands)
• Co-author(s): Rob C van Wijk: Cluster Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
  Elke H J Krekels: Cluster Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
  Vasudev Kantae: Cluster Systems Pharmacology, Division of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
  Amy C Harms: Cluster Systems Pharmacology, Division of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
  Yuanhao Guo: Imaging and BioInformatics, Leiden Institute of Advanced Computer Science (LIACS), Leiden, Netherlands
  Wouter J Veneman: Division of Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden, Netherlands
  Fons J Verbeek: Imaging and BioInformatics, Leiden Institute of Advanced Computer Science (LIACS), Leiden, Netherlands
  Thomas Hankemeier: Cluster Systems Pharmacology, Division of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands
  Herman P Spaink: Division of Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden, Netherlands
  Piet H van der Graaf: Cluster Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden, Netherlands;QSP, Certara, Canterbury, United Kingdom
  
• Abstract:

  Backgrounds

  Zebrafish larvae are increasingly used in drug discovery and development. Characterizing internal drug concentrations over time will improve interpretation of efficacy and toxicity data. Recently we developed a method to quantify drug pharmacokinetics in zebrafish larvae of 3 days post fertilization (dpf) using paracetamol (APAP).

  Aims

  To
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