You can access any of the podium or poster presentations’ abstracts by searching for it below. For the 2026 FIP world congress in Montreal, presentations and summaries from invited speakers are available below, while abstracts are published in the Pharmacy Education Journal (PEJ) here.
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Categorical Modelling of a Rat Behavioural Seizure Scoring System to Define Exposure-Response Relationship and Predict the NOEL
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-092-Monday
- By: NORDELL, Pär (AstraZeneca, Drug Metabolism and Disposition, Mölndal, Sweden)
- Co-author(s): Pär Nordell: Drug Metabolism and Disposition, AstraZeneca, Mölndal, Sweden
Harish Shankaran: Drug Metabolism and Disposition, AstraZeneca, Boston, United States
Karen Tse: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
Glen Hawthorne: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
William Redfern: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
Alex Harmer: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom - Abstract:
Backgrounds
In a exploratory rat study with Compound A convulsions were observed at high doses. Accordingly, a study was conducted at 0, 40 and 100 mg/kg to assess exposures in relation to the seizure behavior scored using the modified Racine scale.Aims
PK/PD modelling was undertaken to establish the exposure-response relationship and define a NOEL.M..
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Last update 23 September 2026