Categorical Modelling of a Rat Behavioural Seizure Scoring System to Define Exposure-Response Relationship and Predict the NOEL

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-092-Monday
• By: NORDELL, Pär (AstraZeneca, Drug Metabolism and Disposition, Mölndal, Sweden)
• Co-author(s): Pär Nordell: Drug Metabolism and Disposition, AstraZeneca, Mölndal, Sweden
  Harish Shankaran: Drug Metabolism and Disposition, AstraZeneca, Boston, United States
  Karen Tse: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
  Glen Hawthorne: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
  William Redfern: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
  Alex Harmer: Drug Metabolism and Disposition, AstraZeneca, Cambridge, United Kingdom
  
• Abstract:

  Backgrounds

  In a exploratory rat study with Compound A convulsions were observed at high doses. Accordingly, a study was conducted at 0, 40 and 100 mg/kg to assess exposures in relation to the seizure behavior scored using the modified Racine scale.

  Aims

  PK/PD modelling was undertaken to establish the exposure-response relationship and define a NOEL.

  M

  ..

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