A semi-mechanistic PK/PD model to elucidate levofloxacin-induced killing and resistance development of Escherichia coli

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-072-Monday
• By: GOEBGEN, Eva (Institute of Pharmacy, Department of Clinical Pharmacy and Biochemistry, Berlin, Germany)
• Co-author(s): Eva B. Goebgen: Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
  Sebastian G. Wicha: Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
  Charlotte Kloft: Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
  
• Abstract:

  Backgrounds

  Emerging resistance is known to be enhanced by misuse of antibiotics.

  Aims

  This project aimed at elucidating the bacterial killing of levofloxacin (LEV) against and the resistance development of Escherichia coli (E. coli) by semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modelling.

  Methods

  To describe in vitro data of resistant E
  ..

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