Human jejunum in the Ussing chamber set-up replicates clinically observed intestinal metabolites

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-061-Monday
• By: AMBERNTSSON, Sara (Astrazeneca, Mölndal, Sweden)
• Co-author(s): Sara Amberntsson: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
  Charlotta Vedin: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
  Katarina Breitholtz: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
  Katherine Fenner: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, United Kingdom
  Constanze Hilgendorf: Safety and ADME translational sciences, Drug safety and metabolism, IMED AstraZeneca, Sweden
  
• Abstract:

  Backgrounds

  Ex vivo studies using fresh intestine in an Ussing chamber set-up are typically used to predict absorption of drug compounds. Metabolism in the gut can be an additional key piece of information when for example loss of absorbed dose is observed in vivo. The Ussing chamber set-up is a comprehensive technique where relevant intestinal..

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