Study of sansalvamide cyclic peptides substituted leucine and valine with proline one by one

• In: SIG Natural Substances - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: NS-P-060
• By: TIAN, Xia (Hebei University of Science & Technology, Shijiazhuang, China)
• Co-author(s): Liu, Shouxin (Hebei University of Science & Technology, SHIJIAZHUANG, China)
  Zhen, Xiaoli (Hebei University of Science & Technology, SHIJIAZHUANG, China)
  Han, Jianrong (Hebei University of Science & Technology, SHIJIAZHUANG, China)
  
• Abstract:

  Sansalvamide A 1 is a cyclic depsipeptide, isolated from a marine fungus of the genus Fusarium by Belofsky 1. The depsipeptide exhibits inhibitor of MCV topoisomerase. The corresponding amide derivatives, sansalvamide A cyclic peptide demonstrated a more significant antitumor activity 2.Previous work by us 3 and McAlpine’s group 4 reported..

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