Potassium channel related mechanisms of mpp+-induced cell death in wild type and alpha-synuclein-transfected sh-sy5y

• In: SIG Pharmaceutical Biotechnology - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: PB-P-003
• By: SHI, Qiaoqiao (Institute of Materia Medica, Beijing, China)
• Co-author(s): Wang, Xiaoliang (Institute of Materia Medica, BEIJING, China)
  
• Abstract:

  Aim: To investigate the mechanisms of the dopaminergic neurons death in Parkinson Disease (PD), we studied the roles of the potassium channel in MPP+-induced cell death in wild type and alpha-synuclein-transfected SH-SY5Y. Methods: Wild type (WT) and A53T mutant alpha-synuclein-transfected SH-SY5Y were exposed to MPP+ (1-methyl-4-phenylpyridinium) ..

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