PHYSICAL SOLID-STATE TRANSITION OF INDOMETHACIN IN SUPERCOOLED LIQUID AND STABILISATION OF AMORPHOUS STATE

• In: Poster Session
• At: Düsseldorf (Germany) (2015)
• Type: Poster
• By: SEMJONOV, Kristian (University of Tartu, Department of Pharmacy, Tartu, Estonia)
• Co-author(s): Kristian Semjonov
  
• Abstract:

  Today, 75% of drugs coming out of pipeline are poorly water-soluble. Numerous approaches have been developed to improve the drug water solubility, e.g., s, amorphous solid dispersions (SDs), co-grindingand electrospinning, however with limited success.

  The SDs were prepared by QC IND and copolymer/sugar alcohol in different ratios. The molten mass

  ..

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