Identification of 5,6-quinolinedione as a potential reactive metabolite of primaquine

• In: Posters C - Drug Design and Discovery
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PC-004
• By: CHIU, Francis (Monash University, CDCO, MIPS, Parkville, Australia)
• Co-author(s): Ryan, Eileen (Monash University, Parkville, Australia)
  Charman, Susan (Monash University, Parkville, Australia)
  
• Abstract:

  Background: The mechanism of primaquine-induced toxicities is unknown but is believed to require metabolic activation. Identification of reactive metabolites will help in understanding of the mechanism of primaquine toxicity. Aim: To identify and characterise reactive metabolites of primaquine, and to examine the mechanism of formation and..

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