On-line solid phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE-HPLC-MS/MS) for quantification of clonazepam in human plasma: an automated method for bioequivalence studies

• In: SIG Bioavailability / Bioequivalence - Poster Session
• At: Salvadore (Brazil) (2006)
• Type: Poster
• Poster code: BB-P-009
• By: GONCALVES, J.C. (Fac Farmácia-UFRJ, Rio De Janeiro, Brazil)
• Co-author(s): Neves de Miranda, Claudia (Fac Farmácia-UFRJ, RIO DE JANEIRO, Brazil)
  Germain Noel, François (Dept Farmacologia - ICB/UFRJ, RIO DE JANEIRO, Brazil)
  Caminha, Ricardo (Hospital Universitário - UFRJ, RIO DE JANEIRO, Brazil)
  Da Silva Gram, Karla (Fac Farmácia-UFRJ, RIO DE JANEIRO, Brazil)
  
• Abstract:

  A validated method for on-line solid phase extraction coupled with high-performance liquid chromatography tandem mass spectrometry (SPE-HPLC-MS-MS) is described for the quantification of Clonazepam in human plasma. The method involves a dilution of 100 uL of plasma with 50 uL of diazepam (2.5 ng/mL), used as internal standard, vortex-mixing,

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