Liposomal 5-fluorouracil for topical drug delivery

• In: Industrial Pharmacy Section - Poster Session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: IPS-P-013
• By: NOUNOU, Mohamed Mahmoud (Pharmacy Faculty, Alexandria University, Department of Pharmaceutics, Alexandria, Egypt)
• Co-author(s): El-Khordagui (Pharmacy Faculty, Alexandria University, ALEXANDRIA, Egypt)
  Khalafallah (Pharmacy Faculty, Alexandria University, ALEXANDRIA, Egypt)
  Khalil (Pharmacy Faculty, Alexandria University, ALEXANDRIA, Egypt)
  
• Abstract:

  Effective topical therapy with 5-fluorouracil (5-FU) requires sustained availability of the drug at a minimum effective concentration in deeper skin layers with minimal systemic absorption. A liposomal 5-FU delivery system may fulfill such requirements although it presents formulation challenges because of the drug hydrophilicity and low molecular ..

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