Development of tacrolimus sustained-release tablet prepared by solid dispersion system

• In: Industrial Pharmacy Posters
• At: Lisbon (Portugal) (2010)
• Type: Poster
• Poster code: IPS-P-013
• By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, South-Korea)
• Co-author(s): Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  Yeo, Woohyun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  Yi, Jeong-Hun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  Hwang, Doohyung (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  Cho, Jung Hyun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  Yang, Kwanyeol (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  Oh, Dong Hoon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  
• Abstract:

  The purpose of this study is to develop a sustained-release tablet with similar dissolution profile and bioavailability to that of the commercial tacrolimus sustained-release capsule. Tacrolimus-loaded solid dispersion with enhanced solubility was prepared by spray-drying method and their physicochemical properties were investigated. Among the..

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