Effect of losartan on drug metabolism by human liver microsomes with cyp isoform variants

• In: Individualised Medicine - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: IM-P-004
• By: INOTSUME, Nobuo (Hokkaido Pharmaceutical University, Otaru, Japan)
• Co-author(s): Toda, Takaki (Hokkaido Pharmaceutical University, OTARU, Japan)
  Kudo, Seiichiro (Hokkaido Pharmaceutical University, OTARU, Japan)
  Mukai, Yuji (Hokkaido Pharmaceutical University, OTARU, Japan)
  Mori, Akinori (Hokkaido Pharmaceutical University, OTARU, Japan)
  Yamawaki, Mitsuyoshi (Hokkaido Pharmaceutical University, OTARU, Japan)
  Hayakawa, Toru (Hokkaido Pharmaceutical University, OTARU, Japan)
  Eliasson, Erik (Karolinska Institute, STOCKHOLM, Sweden)
  Ask, Birgitta (Karolinska Institute, STOCKHOLM, Sweden)
  Rane, Anders (Karolinska Institute, STOCKHOLM, Sweden)
  
• Abstract:

  Objective: We have already found that losartan inhibits metabolism of arachidonic acid, which is mainly metabolized by CYP2C8, 2C9, and 2J2, in human liver microsomes. In this study, we have performed to demonstrate inhibition of paclitaxel and fluvastatin metabolism using human liver microsomes with 2C8 and 2C9 variants.
  
  
  
  Methods: Human liver ..

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