Thermo-responsive estrogen receptor-fusions for spatiotemporal control of signaling/gene regulation

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-BIO-002
• By: TRUONG, Anh (University of Southern California, Pharmacology and Pharmaceutical Sciences)
• Co-author(s): Anh Tan Truong: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States
  Zhe Li: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States
  Curtis Okamoto: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States
  J. Andrew MacKay: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States;Department of Biomedical Engineering, University of Southern California, Los Angeles, United States
  
• Abstract:

  Background

  Aberrant signaling resulting as a consequence of dysregulation of the nuclear hormone estrogen receptor α (ERα) pathway has been implicated in the development of numerous diseases. Understanding how signaling and transcription occur require precise manipulation of the cells’ machinery and while small-molecule inhibitors have been

  ..

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