Agmatine extracts anticonvulsant effect in mice: modulation by alpha-2 adrenoceptors and nitric oxide

• In: Academic Pharmacy Section Posters
• At: New Orleans (USA) (2004)
• Type: Poster
• Poster code: AS-P009
• By: ROSHANZAMIR, Farshad (Shaheed Beheshti School of Pharmacy, Pharmacology, Tehran, Iran)
• Co-author(s): Demehri (Tehran School of Medicine, Iran)
  Dehpour (Tehran School of Medicine, Iran)
  
• Abstract:

  The effect of agmatine, an endogenous polyamine metabolite, on seizure susceptibility was investigated in mice. Acute intraperitoneal administration of agmatine (5, 10, 20, 40 mg/kg) had a significant and dose-dependent inhibitory effect on pentylenetetrazole (PTZ)-induced seizures. The peak of this anticonvulsant effect was 45 min after agmatine..

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