Biorelevant tests combined with a Physiologically Based Pharmacokinetic Model predict the in vivo behaviour of Ciprofloxacin

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-C-028-Monday
• By: HANSMANN, Simone (Goethe University, Institute of Pharmaceutical Technology, Frankfurt, Germany)
• Co-author(s): Simone Hansmann: Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
  Jennifer Dressman: Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
  
• Abstract:

  Backgrounds

  Physiologically based Pharmacokinetic Models

  Aims

  The aim of this study was 1) to investigate the behaviour of ciprofloxacin, a BCS Class IV weakly basic drug, under conditions simulating the upper GI tract in humans using in vitro dissolution in single media, in a two-stage method and in transfer experiments and 2) to simulate the plasma

  ..

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