Characterization of Surface Properties of Glass Vials Used as Primary Packaging Material for Parenterals.

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-C-014-Monday
• By: DITTER, Dominique (Basel, Switzerland)
• Co-author(s): Dominique Ditter: Late-Stage Pharmaceutical and Processing Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  Alejandra Nieto: Late-Stage Pharmaceutical and Processing Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  Holger Roehl: Late-Stage Pharmaceutical and Processing Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  Michael Wahl: Institut für Oberflächen- und Schichtanalytik GmbH , Kaiserslautern, Germany
  Joerg Huwyler: Pharmaceutical Technology, University of Basel, Basel, Switzerland
  Hanns-Christian Mahler: Pharmaceutical Technology, University of Frankfurt, Frankfurt, Germany
  Andrea Allmendinger: Late-Stage Pharmaceutical and Processing Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  
• Abstract:

  Backgrounds

  Glass delamination and the "fogging" phenomenon are two major issues within the pharmaceutical industry that are attributed to the properties of the vial inner surface in contact with the drug product. Glass delamination is a critical defect of a drug product and lead to various recalls. Vial fogging can be observed after lyophilization ..

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