Lipid mimetic, lymph-directing prodrugs of testosterone facilitate oral bioavailability via avoidance of first-pass metabolism

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-083-Tuesday
• By: HU, Luojuan (Monash University, Faculty of Pharmacy and Pharmaceutical Sciences, Melbourne, Australia)
• Co-author(s): Luojuan Hu: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
  Sifei Han: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
  Tim Quach: Medicinal Chemistry, Monash University, Melbourne, Australia
  Shea Lim: Medicinal Chemistry, Monash University, Melbourne, Australia
  Natalie Trevaskis: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
  Jamie Simpson: Medicinal Chemistry, Monash University, Melbourne, Australia
  Christopher Porter: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
  
• Abstract:

  Backgrounds

  Hepatic first-pass metabolism limits the oral bioavailability of drugs such as testosterone (TST). Drug transport through the lymphatic system avoids first pass metabolism since intestinal lymph drains into the systemic circulation via the thoracic duct, bypassing the liver. Dietary triglyceride (TG) is transported via the lymphatics

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