Pharmacokinetic evaluation of doxorubicin containing lipiodol-based emulsion and drug-eluting beads used in the treatment of intermediate hepatocellular carcinoma

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-078-Tuesday
• By: DUBBELBOER, Ilse (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
• Co-author(s): Ilse R. Dubbelboer: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Elsa Lilienberg: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Amar Karalli: Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden;Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
  Rimma Axelsson: Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden;Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
  Torkel B. Brismar: Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden;Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
  Charlotte Ebeling Barbier: Department of Radiology, Uppsala University Hospital, Uppsala, Sweden
  Agneta Norén: Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
  Frans Duraj: Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
  Ulf Bondesson: Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), Uppsala, Sweden
  Mikael Hedeland: Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), Uppsala, Sweden
  Erik Sjögren: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Per Stål: Unit of Gastroenterology, Department of Internal Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden;Department of Digestive Diseases, Karolinska University Hospital in Huddinge, Stockholm, Sweden
  Rickard Nyman: Department of Radiology, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
  Hans Lennernäs: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  
• Abstract:

  Backgrounds

  Doxorubicin containing lipidodol-based emulsions (LIPDOX) and drug-eluting beads (DEBDOX) are used in the treatment of hepatocellular carcinoma. Although profoundly different from a pharmaceutical perspective, both drug delivery systems are equally effective at treating the illness.

  Aims

  The aim of this study was to compare the in vivo
  ..

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