iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening studies

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-073-Tuesday
• By: BRODIN, Birger (University of Copenhagen, Department of Pharmacy, Copenhagen, Denmark)
• Co-author(s): Burak Ozgür: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  Lasse Saaby: Bioneer-Pharma, University of Copenhagen, Copenhagen,
  Birger Brodin: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  
• Abstract:

  Backgrounds

  The efflux transporter P-glycoprotein (P-gp, product of the MDR1/ABCB1 gene) hinders uptake of drug compounds to the brain, limits intestinal uptake, is a cause of resistance to chemoterapeutics and a potential "site" for drug-drug interaction . Regulatory agencies therefore recommend that new API's are evaluated with respect to P-gp..

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