Introduction of a new in vitro approach for prediction of drug-drug interactions based on measurement of intracellular unbound concentrations of time-dependent inhibitors of CYP3A4

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-041-Tuesday
• By: FILPPULA, Anne (Uppsala, Sweden)
• Co-author(s): Rezvan Parvizi: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Anne M Filppula: Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden
  André Mateus: Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Pawel Baranczewski: Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden;SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics facility, Department of Pharmacy, Uppsala University, Uppsala,
  
• Abstract:

  Backgrounds

  Time-dependent inhibition (TDI) of cytochrome P450 (CYP) 3A4 may result in severe and long-lasting clinical drug-drug interactions (DDIs). However, predictions based on in vitro TDI data tend to over-estimate the risk of DDIs, likely due to conservative inhibitor concentration estimates (Vieira et al, 2014).

  Aims

  The aim of this study was
  ..

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