Lipid-Coated Stealth Nanoparticles of Novel Hydrophobic Prodrug, Niclosamide Stearate, as Cancer Therapeutic: Formulation and Physico-Chemical Characterization of Nanoparticles

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-056-Monday
• By: WALKE, Prasad (University of Southern Denmark, Center for Single Particle Science and Engineering, Odense, Denmark)
• Co-author(s): Prasad Walke: Center for Single Particle Science and Engineering, University of Southern Denmark, Odense, Denmark
  Pablo Hervella: Center for Single Particle Science and Engineering, University of Southern Denmark, Odense, Denmark
  David Needham: Center for Single Particle Science and Engineering, University of Southern Denmark, Odense, Denmark
  
• Abstract:

  Backgrounds

  Working with the concept of designing LDL-like nanoparticles to 'Put the drug in cancer’s food', here we present the design of such nanoparticles (NPs) using a hydrophobic prodrug Niclosamide Stearate (NS) coated with a mixture of phospholipid, PEG lipid and cholesterol at specific ratio. LDL particles (~25 nm) are known to be massively

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