Changes in Indomethacin Solubility in Mixtures with Basic Drugs

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-044-Monday
• By: SHIMADA, Yohsuke (Tokyo University of Science, Faculty of Pharmaceutical Sciences, Noda, Japan)
• Co-author(s): Yohsuke Shimada: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
  Ryo Tateuchi: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
  Satoru Goto: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
  
• Abstract:

  Backgrounds

  A mixture of indomethacin (IND), an acidic nonsteroidal anti-inflammatory drug, and lidocaine (LID), a local anesthetic (LA), forms a eutectic complex, which has a low melting point that is near room temperature. The aqueous solubility of the mixture is greater than that of IND or LID alone, improving the bioavailability of IND. 

  Aims

  Ther
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