Molecular association model of Peroxisome Proliferator-Activated Receptor α and its new specific and efficient ligand, K-877

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-075-Tuesday
• By: TOKIWA, Hiroaki (Rikkyo Universiry, Department of Chemistry, Tokyo, Japan)
• Co-author(s): Yurina Miyashita: Department of Chemistry, Rikkyo Universiry, Tokyo, Japan;AMED-CREST, JST, Tokyo, Japan
  Kenta Takei: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan
  Vladimir Sladek: Department of Chemistry, Rikkyo Universiry, Tokyo, Japan;AMED-CREST, JST, Tokyo, Japan
  Shogo Nakano: Department of Food Sciences, University of Shizuoka, Shizuoka, Japan;AMED-CREST, JST, Tokyo, Japan
  Shohei Ito: Department of Food Sciences, University of Shizuoka, Shizuoka, Japan;AMED-CREST, JST, Tokyo, Japan
  Takeshi Matsuzaka: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
  Motohiro Sekiya: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
  Yoshimi Nakagawa: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
  Hiroaki Tokiwa: Department of Chemistry, Rikkyo Universiry, Tokyo, Japan;AMED-CREST, JST, Tokyo, Japan
  Hitoshi Shimano: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
  
• Abstract:

  Backgrounds

  Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of  nuclear receptor superfamily.  PPARα is a regulator that activates fatty acid oxidation and improves hypertriglyceridemia.  K-877 is a novel selective PPARα modulator (SPPARMα) to activate PPARα transcriptional activity. 

  Aims

  The main
  ..

The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login