Anti-metastatic effect of Clopidogrel is associated with inhibition of invasiveness in B16-BL6 mouse melanoma cells

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-072-Tuesday
• By: YOSHIKAWA, Noriko (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Pharmacology I, Nishinomiya, Japan)
• Co-author(s): Noriko Yoshikawa: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
  Mayuko Hatai: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
  Eriko Kinoshita: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
  Satomi Kagota: Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
  Kazumasa Shinozuka: Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
  Kazuki Nakamura: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
  
• Abstract:

  Backgrounds

  Clopidogrel, a derivative of thienopyridine, inhibits platelet aggregation through the inhibition of P2Y₁₂ receptor, then used to reduce the risk of heart disease and stroke. We previously demonstrated that orally administered Clopidogrel inhibited lung metastasis in mice intravenously injected with B16-BL6 mouse melanoma cells.

  Aims

  In
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