Analysis of physicochemical properties of self-nanoemulsion constructed from environment sensitive ionizable lipid

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-070-Tuesday
• By: TANAKA, Hiroki (Hokkaido University, Faculty of Pharmaceutical Scieces, Sapporo, Japan)
• Co-author(s): Hiroki Tanaka: Faculty of Pharmaceutical Scieces, Hokkaido University, Sapporo, Japan
  Sho Oasa: Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
  Masataka Kinjo: Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
  Kota Tange: NOF Corporation, Kawasaki, Japan
  Yuta Nakai: NOF Corporation, Kawasaki, Japan
  Hideyoshi Harashima: Faculty of Pharmaceutical Scieces, Hokkaido University, Sapporo, Japan
  Hidetaka Akita: Faculty of Pharmaceutical Scieces, Chiba University, Chiba, Japan
  
• Abstract:

  Backgrounds

  Ionizable lipids with tertiary amines have been developed as promising materials for nucleic acid therapy. Neutral surface of a carrier formed with an ionizable lipid is advantageous to its pharmacokinetics/intracellular trafficking since unspecific electrostatic interaction with biomaterials can be avoided. Furthermore, an ionizable..

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