RNAi accessory factor TAR-RNA binding protein is involved in anti-viral innate immunity against Picornavirus infection

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-055-Tuesday
• By: KOMURO, Akihiko (Niigata University of Pharmacy and Applied Life Sciences, Biochemistry, Niigata, Japan)
• Co-author(s): Akihiko Komuro: Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
  Curt Horvath: Department of Molecular Biosciences, Northwestern University, Evanston, United States
  
• Abstract:

  Backgrounds

  Picornavirus cause clinical symptoms such as aseptic meningitis, encephalitis, myocarditis, and hepatitis etc. RNA helicase proteins, RIG-I, MDA5 and LGP2 detect viral RNAs in infected cells. Sensing of viral RNAs by these sensors rapidly initiate anti-viral responses. LGP2 and MDA5 cooperatively detect Picornavirus RNAs, although

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