Impact of Drug Distribution within the Liver on Measurement of Metabolic Elimination Rate Constants (k) and Clearance (CL)

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-044-Tuesday
• By: SODHI, Jasleen (University of California San Francisco, Bioengineering and Therapeutic Sciences, San Francisco, United States)
• Co-author(s): Jasleen Sodhi: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  Leslie Benet: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  
• Abstract:

  Backgrounds

  Drug discovery requires accurate prediction of human hepatic CL. However, universally accepted methods of in vitro-to-in vivo extrapolation (IVIVE) underpredict in vivo values by ~9 fold, and vary by drug. Models consider the liver as homogenous, rather than a heterologous environment composed of both aqueous and lipophilic regions into ..

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