Discovery of a BD1 selective inhibitor of BRD4 and co-targeting its interaction with AMPK-modulating autophagic cell death in breast cancer

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-036-Tuesday
• By: LIU, Bo (Chengdu, China)
• Co-author(s): Leilei Fu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan university, Chengdu, China
  Bo Liu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan university, Chengdu, China
  
• Abstract:

  Backgrounds

  BRD4 is an attractive cancer target, yet its protein-protein interactions (PPIs), which is relevant to therapeutic effects of BRD4 inhibitors, are not well understood. Induction of autophagic cell death (ACD) has been emerging as a new strategy; therefore, targeting ACD for discovering a BRD4 inhibitor will be anticipated.

  Aims

  Discovery
  ..

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