Biological responsiveness and pharmacokinetic properties of cellular type hemoglobin based oxygen carrier (Hemoglobin-Vesicles) in hyperlipidemia model mice after massive intravenous injection

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-028-Tuesday
• By: TAGUCHI, Kazuaki (Sojo University, Kumamoto, Japan)
• Co-author(s): Kazuaki Taguchi: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
  Keishi Yamasaki: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
  Hiromi Sakai: Department of Chemistry, Nara Medical University, Nara, Japan
  Toru Maruyama: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  Masaki Otagiri: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
  
• Abstract:

  Backgrounds

  The hemoglobin-vesicle (HbV), a liposome in which a concentrated human hemoglobin solution is encapsulated, was developed as an artificial oxygen carrier. Although it has been demonstrated that HbV possesses a favorable safety, metabolic, and excretion performance in healthy animals, biological response and metabolic performance under..

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