Induction of Mitophagy-mediated Antitumor Activity with Folate-appended Methyl-β-cyclodextrin

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-008-Tuesday
• By: MOTOYAMA, Keiichi (Kumamoto University, Graduate School of Pharmaceutical Sciences, Kumamoto, Japan)
• Co-author(s): Keiichi Motoyama: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  Nao Tanaka: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  Yuki Yamashita: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  Taishi Higashi: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  Hidetoshi Arima: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;, Program for Leading Graduate School "HIGO (health life science: Interdisciplinary and Glocal Oriented) Program", Kumamoto University, Kumamoto, Japan
  
• Abstract:

  Backgrounds

  size: small;">Mitophagy is the specific autophagic elimination of mitochondria, which regulates cellular survival via the removal of damaged mitochondria. Recently, we revealed that folate-appended methyl-βsize: small;">-cyclodextrin (FA-M-βsize: small;">-CyD) provided selective antitumor activity in folate receptor-αsize: small;"> (FR-α

  ..

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