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Evaluating predictors of paclitaxel-associated peripheral neuropathy: a pharmacodynamic modelling approach
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-109-Monday
- By: WILLIAMS OJARA, Francis (Freie Universitaet Berlin, Germany, Clinical Pharmacy & Biochemistry, Institute of Pharmacy, Berlin, Germany)
- Co-author(s): Francis Williams Ojara: Clinical Pharmacy & Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Germany, Berlin, Germany
Andrea Henrich: Clinical Pharmacy & Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Germany, Berlin, Germany
Markus Joerger : Medical Oncology and Hematology, Cantonal Hospital, St Gallen, Switzerland
Charlotte Kloft : Clinical Pharmacy & Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Germany, Berlin, Germany - Abstract:
Backgrounds
Peripheral neuropathy (PN) is a dose limiting, cumulative adverse event of paclitaxel (PTX) with relevant negative impact on patient’s quality of life (QoL). PTX dose and exposure (time above a threshold plasma concentration of 0.05 μM, TC>0.05) are known predictors of PN from standard statistical tests with a single severity grade per.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 2 July 2026