Analysis of Simultaneous 6-mercaptopurine and Its Metabolites in Dried Blood Spot Using LC-MS/MS: Application of The Method to Support Therapeutic Drug Monitoring

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-075-Monday
• By: HARAHAP, Yahdiana (Universitas Indonesia, Faculty of Pharmacy, Depok, Indonesia)
• Co-author(s): Yahdiana Harahap: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Supandi supandi: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Harmita harmita: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Rizka Andalusia: Research and Development, Dharmais Cancer Hospital, Jakarta, Indonesia
  Marlina Ika: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Nurul Azizah: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  
• Abstract:

  Backgrounds

  6-Mercaptopurine (6-MP) is an antineoplastics drug which has narrow therapeutic index, therefore therapeutic drug monitoring is needed to be done. Dried blood spot (DBS) bio sampling method application for 6-Mercaptopurine on childhood Acute Lymphocytic Leukemia (ALL) provides comfort compared with venipuncture. However due to small..

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