BDDCS Classification Does Not Support BSEP Inhibition As Being DILI Causative

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-069-Monday
• By: CHAN, Rosa (University of California San Francisco, Bioengineering and Therapeutic Sciences, San Francisco, United States)
• Co-author(s): Rosa Chan: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  Leslie Benet: Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  
• Abstract:

  Backgrounds

  Drug-induced liver injury (DILI) is a leading cause of drug failure and a major reason for drug withdrawals from the market. Some primary compound-specific mechanisms linked to DILI include: cytotoxicity, reactive metabolite formation, inhibition of the bile salt export pump (BSEP), and mitochondrial dysfunction. 

  Aims

  The present study

  ..

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