The Effect of Protein Binding on the Interaction Between Transporters and Highly Protein Bound Drugs

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-066-Monday
• By: BOWMAN, Christine (San Francisco, United States)
• Co-author(s): Christine Bowman: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
  Hideaki Okochi: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
  Leslie Benet: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
  
• Abstract:

  Backgrounds

  Accurately predicting hepatic clearance from in vitro results is crucial in the selection process of new molecular entities for clinical development.  However, current in vitro-in vivo extrapolation methods often lead to underprediction, particularly for compounds that are highly protein bound and substrates for uptake transporters.

  Aims

  T
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