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Acamprosate has no impact on the permeability of paracellular markers across Caco-2 cells
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-062-Monday
- By: ANTONESCU, Irina (University of Southern Denmark, Department of Physics, Chemistry and Pharmacy, Odense, Denmark)
- Co-author(s): Irina Antonescu: Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark
Sibylle Neuhoff: Simcyp Ltd., a Certara company, Sheffield, United Kingdom
Bente Steffansen: Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark - Abstract:
Backgrounds
The oral bioavailability of poorly permeable and non-metabolised acamprosate (BCS III) is 11%. It is controversial whether the intestinal effective permeability of the fully an-ionized acamprosate (pKa 1.83; MW 181.2 g/mol) is predominantly paracellular (Ppara) or transcellular. An initial physiologically-based pharmacokinetic model.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 2 July 2026