Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-052-Monday
• By: XIAO, Qiong (Beijing, China)
• Co-author(s): Qiong Xiao: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Xiaojian Wang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Huaqing Cui: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Hui Wen: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Meiyang Xi: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Xiang Zhang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  
• Abstract:

  Backgrounds

  SYL927 and SYL930 are selective S1P1 agonists under preclinical development. However, during their pharmacokinetic studies we detected two metabolites in rat blood that were tentatively identified as monohydroxylated metabolites of SYL927 and SYL930 based on LC–MS/MS data

  Aims

  Identify the monohydroxylated metabolites

  Methods

  We designed
  ..

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