Design, Synthesis and Testing of novel small molecule inhibitors of S-phase Kinase-Associated Protein 2

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-022-Monday
• By: LIU, Ran (Belrose, Australia)
• Co-author(s): Ran Liu: Faculty of Pharmacy, University of Sydney, Sydney, Australia
  Paul Groundwater: Faculty of Pharmacy, University of Sydney, Sydney, Australia
  David Hibbs: Faculty of Pharmacy, University of Sydney, Sydney, Australia
  Thomas Grewal: Faculty of Pharmacy, Universit
  
• Abstract:

  Backgrounds

  S-Phase Kinase-associated Protein 2 (Skp2), an oncoprotein, is overexpressed in numerous human cancers and plays a critical role in cell cycle progression, senescence, cancer progression and metastasis, through promoting th

  Aims

  Our project aims to develop small molecules which inhibit the interaction of Skp2 and p27, a process which is

  ..

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