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Effects of berberine on the transport of p-gp substrates across caco-2 and l-mdr1 cell monolayers
- In: SIG Natural Substances - Posters
- At: Beijing (China) (2007)
- Type: Poster
- Poster code: NS-P-069
- By: XIN, Huawen (Wuhan General Hospital, Wuhan, China)
- Co-author(s): Wu, Xiao-Chun (Wuhan General Hospital, WUHAN, China)
Li, Qing (Wuhan General Hospital, WUHAN, China)
Yu, Ai-Rong (Wuhan General Hospital, WUHAN, China) - Abstract:
AIM To investigate the effects of berberine (BBR) on the transport of P-gp substrates including cyclosporine A (CsA) and digoxin across Caco-2 and L-MDR cell monolayers. METHODS Permeability coefficients and transport rates of digoxin and CsA across Caco-2 and L-MDR1 monolayers were measured in the presence of BBR(50µM-5mM). RESULTS The..
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Last update 23 September 2026