First synthesisof 12-oxosoladucidine and its derivatives as potential anti-tumor steroidal alkaloids

• In: SIG Natural Substances - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: NS-P-056
• By: ZHA, Xiaoming (China Pharmaceutical University, Nanjing, China)
• Co-author(s): Hou, Yingwei (China Pharmaceutical University, NANJING, China)
  Sun, Hongbin (China Pharmaceutical University, NANJING, China)
  Zhang, Yihua (China Pharmaceutical University, NANJING, China)
  
• Abstract:

  First synthesis of 12-oxosoladucidine 4 and its derivatives as potential anti-tumor steroidal alkaloids is described. Starting from hecogenin 5, 4 was prepared in five steps with overall yield 31%. Moreover, 8 derivatives of 4 were synthesized. First synthesis of 12-oxosoladucidine 4 and its derivatives as potential anti-tumor steroidal alkaloids..

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