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Production of the antimalarial drug precursor amorpha-4,11-diene and artemisinic acid in engineered yeast
- In: SIG Pharmaceutical Biotechnology - Posters
- At: Beijing (China) (2007)
- Type: Poster
- Poster code: PB-P-021
- By: KONG, Jianqiang (Institute of Materia Medica, Beijing, China)
- Co-author(s): Wang, wei (Institute of Materia Medica, BEIJING, China)
Zhu, ping (Institute of Materia Medica, BEIJING, China)
Dai, jungui (Institute of Materia Medica, BEIJING, China) - Abstract:
Two genes encoding amorpha-4,11-diene synthase(ADS) and amorpha-4,11-diene hydroxylase (CYP71AV1 P450)were cloned from Artemisia annua L. The two genes were related to artemisinin biosynthesis. The other two genes encoding the FPP synthase and HMG-CoA reductase were cloned from Saccharomyces cerevisiae. All cloned cDNAs were confirmed by DNA..
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