FORMULATION AND EVALUATION OF COMBINED BACLOFEN AND TIZANIDINE HYDROCHLORIDE TRANSDERMAL PATCHES

• In: Poster Session
• At: Düsseldorf (Germany) (2015)
• Type: Poster
• By: CHUN, In Koo (Dongduk Women's University, College of Pharmacy, Seoul, South-Korea)
• Abstract:

  Baclofen (BC) inhibits GABA receptor, whereas tizanidine hydrochloride (TZ) effects on α₂ receptor to hinder neurotransmitter release. Both drugs are muscle relaxants and antispastic drugs, but have short half-lives and low bioavailabilities, and are orally administered three times a day.

  To select vehicles for BC and TZ, solubility studies were

  ..

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