DISCOVERY AND BIOLOGICAL EVALUATION OF NOVEL 1,2,4-TRIAZINE DERIVATIVES AS C-MET KINASE INHIBITORS

• In: Poster Session
• At: Düsseldorf (Germany) (2015)
• Type: Poster
• By: LABOUTA, Ibrahim (Alexandria University, Faculty of Pharmacy, Pharmaceutical Chemistry, Alexandria, Canada)
• Co-author(s): Ibrahim Labouta
  
• Abstract:

  Tyrosine kinase c-Met is the high-affinity receptor for hepatocyte growth factor (HGF) and HGF/c-Met axis is often dysregulated in tumors. Recent strategies have been employed to interrupt the c-Met signaling pathway. Significant progress was made to develop small-molecule c-Met inhibitors, some of which reached clinical trials. Among heterocycles

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