Docking studies, synthesis, characterization and evaluation of antitumor activity of some novel thiazine substituted 9-anilinoacridines and their 3d qsar studies

• In: Posters: Drug Design and Discovery
• At: Bangkok (Thailand) (2014)
• Type: Poster
• Poster code: POS-DDD009
• By: RAJAGOPAL, Kalirajan (JSS College of Pharmacy, Department of Pharmaceutical Chemistry, The nilgiris, India)
• Co-author(s): Sundaram, Sankar (JSS College of Pharmacy, The nilgiris, India)
  Selvaraj, Jubie (JSS College of Pharmacy, Ootacamund, India)
  
• Abstract:

  Background information:
  Acridine analogues bearing substituted bulky 9-amino functionalities are shown to inhibit topoisomerase II, relaxation of super coiled DNA are important drugs in treatment of cancer.
  Aims
  Based on the above background, A series of novel thiazine substituted 9-anilinoacridines were synthesized and evaluated for antitumor..

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