Systems pharmacology models to assess immunogenicity

• In: Symposium A4: Systems pharmacology –innovative approaches to drug safety on Wednesday, 24 May 2017, 10:40-11:05
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: VICINI, Paolo (MedImmune, Clinical Pharmacology and DMPK, Cambridge, United Kingdom)
• Co-author(s): Paolo Vicini: Clinical Pharmacology and DMPK, MedImmune, Cambridge, United Kingdom
  
• Abstract:

  Immunogenicity is an unwanted immune system reaction that can affect biologic drugs' pharmacokinetics (PK) and pharmacodynamics (PD) [1]. Quantitative systems pharmacology (QSP), an emerging discipline which applies systems biology principles to the study of drugs [2], seeks to characterize drug action in living systems using computer models and

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